Solidified halogenized fat and process of making same.



UNITED STATES Patented November 8, 1904. I

PATENT OEEicE'.

THE FIRM OF E.

MEROK, OF DARMSTADT, GERMANY.

SOLIDIFIED HALOGENIZED FAT AND PROCESS OF MAKING SAME.

SPECIFICATION formingpart of Letters Patent No. 774,224, dated November8, 1904. Application filed June 30, 1903. Serial No. 163,725. (Nospecimens.)

To (all whom, it TIZ/fLZ/ concern:

Be it known that I, HUGO WINTERNITZ, a subject of the Emperor ofAustria-Hungary, residingat Halle-on-the-Saale, Germany,have inventedcertain new and useful Improvements in Solidified Halogenized Fats andProcesses of Making Same, of which the following is a clear, full, andexact description.

My invention relates to a new productviz., solidified halogenizedfatsand also to a process of producing the same.

My invention will be defined in the claims.

The iodized and brominized fats prepared and introduced by me which havebeen the object of physiological study and for which the German Empirehas issued a patent bearing the number 96A95 have since theirintroduction acquired great importance in therapv, and this is moreparticularly the case in regard to the iodized sesame-oil and brominizedsesame-oil. The internal administration of these remedies has, however,been greatly hampered heretofore because of their oily character andincident oleaginous taste. Therefore to prepare the halogenized-and bythisI mean only the iodized or brominized fats in a solid, which may bea pulverulent form and without any loss of the specific virtues whichrender the preparations so valuable, must be regarded as a praiseworthytask. This task or object has been accomplished by evaporating,preferably in a vacuum, the emulsion resulting from the mixture of sucha halogenized fat with concentrated milk, or, instead of the latter,mixing the chief constituents of milkfor example, casein or salts ofcasein and milksugarwith the fat and then reducing the mixture todryness, prefer ably by evaporating it in a vacuum. By casein I alsoinclude compositions containing casein and such substances (an alkali,for example) which render the casein more soluble. By fat I mean toinclude the word oil, and do not limitmyself to any particular class offats or oils, and by pulverulent I merely mean that the substance is inseparated particles.

Example 1: Skim-milk is evaporated in a vacuum to a thick syrupyconsistency and mixed with an iodized fat, preferably iodized 5sesame-oil (one liter of skim-milk to from fifty to one hundred grams ofiodized oil) to form an emulsion. On evaporating to dryness in a vacuumthe emulsion so obtained there results an agreeably-tasting powder whichcontains at least fifty per cent. of iodized sesameoil. It will beobserved that in this example the casein is not precipitated from themilk, but is present in the product resulting from the evaporation ofthe skim-milk.

Example 2: The casein precipitated from one liter of skim-milk isexpressed until the residue contains about thirty per cent. of drysubstance. To the press-cake so obtained a sufiicient quantity of analkali is added to 5 bring it to a creamy consistency, for whichpurpose, for instance, about five cubic centimeters of a ten per cent.solution of sodium carbonate sufliices. Forty grams of milksugar are nowadded and stirred into the mass 7 obtained, as above described, and theresulting pasty mass is then emulsionized With eighty grams ofbrominized fat-e. 5 sesame-oil. This mass is then evaporated to drynessat a low temperature in a vacuum.

Example 3: Twenty grams of a casein salt containing casein and an alkali(soda, for example) are triturated with thirty grams of milk-sugar, themixture moistened by the addition of thirty grams of water, and theresulting paste emulsionized with forty five grams of iodizedsesame-oil. The emulsion so obtained is then evaporated to dryness in avacuum by the air or warmth.

These brominized fats may be used as a 5 sedative and anti-epileptic,and the dose may be from one to four teaspoonfuls, according to theamount of bromin desired to be administered. The iodized fats may beused as an antisyphilitic and alterative, the dose being 9 similarlyvaried according to the amount of iodin to be administered.

The foregoing shows examples of my process and also of productsresulting from my process; but I do not limit myself to the particularoils or fats specified, as 1 am aware that many variations from theexamples set forth can be made without departing from my invention asclaimed.

hat I claim is l. A substance in the form of a solidified fat, saidsubstance containing a halogenized fat and casein.

2. A substance in the form fat, said substance containing vegetable fatand casein.

3. A substance in the form of a solidified fat, said substancecontaining brominized sesame-oil and casein.

4. A substance in the form of a solidified fat, said substancecontaining a halogenized fat, casein and sugar of milk.

5. A substance in the form of a solidified fat, said substancecontaining a brominizcd vegetable oil, casein and sugar of milk.

6. The process of preparing a solidified halogenized fat which consistsin emulsifying a halogenized fat with casein, and evaporating theemulsion to a solid form.

of a solidified a halogcmzed 7. The process of preparing a solidifiedhalogenized fat which consists in emulsifying a halogenized fat withcasein and milk-sugar and evaporating the emulsion to a solid form.

8. The process of preparing a solidified halogenized fat which consistsin emulsifying a brominized fat with casein and evaporating the emulsionto a solid form.

9. The process of preparing a solidified halogenized fat which consistsin emulsifying a halogenized fat with casein and reducing the emulsionto a solid form.

10. The process of preparing a solidified brominized fat, which consistsin emulsifying a brominized sesame-oil with casein and reducing theemulsion to a solid form.

Signed at Leipzig, Germany, this 13th day of June, 1903.

HUGO WVINTERNITZ.

Witnesses:

RUDoLrir FRIOKE, P. V. V. DUNN.

